The Mystery of the Raindrop Skull

A 46-year-old man presents with fatigue, weight loss, back pain, and Hypercalcemia. Radiographs reveal a ‘raindrop skull.’ What’s the diagnosis?

Multiple myeloma


A 46-year-old man presented to the emergency department with a 1-month history of fatigue, shortness of breath, and low back pain and report of a weight loss of 30 kg over the previous 10 months. On physical examination, his conjunctiva and palms were pale. Laboratory evaluation revealed impaired kidney function and hypercalcemia. Radiographs demonstrated a “raindrop skull.” What is the diagnosis?

What is the most likely diagnosis?

Amyloidosis
Systemic lupus erythematosus
Hodgkin’s lymphoma
Paget’s disease
Multiple myeloma

Bone Pain, Hematology, Hypercalcemia, Multiple myeloma, Raindrop skull

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