The Split-Colored Newborn

A neonate with a heart condition develops a striking unilateral Erythema. Explore this benign, transient vascular phenomenon seen in newborns.

Infant harlequin syndrome


A male neonate with an antenatal diagnosis of Ebstein’s anomaly had respiratory distress with low oxygen saturation immediately after birth at 35 weeks of gestation. He was intubated and received infusions of alprostadil and dobutamine. On the third day of life, a clearly demarcated erythema developed on one side of the body as shown in the image. During this episode, the physical examination was otherwise unremarkable, with no changes in vital signs. What is the most likely diagnosis?

What is the most likely diagnosis?

Nascent hemangioma of infancy
Hypercarbic flush
Infant harlequin syndrome
Reactive hyperemia of heart failure
Klippel-Trénaunay syndrome

Alprostadil, Dermatology, Infant harlequin syndrome, Neonate, Vascular phenomenon

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