A 30-year-old presents with skin lesions. Learn how velvety plaques can be a critical paraneoplastic sign of an underlying malignancy, like Gastric cancer.
A 30-year-old woman presented with a 3-month history of progressive skin lesions on her face. On physical examination, there were hyperpigmented, yellow, papillomatous papules and plaques on the face (left). Hyperpigmented velvety plaques were also seen on the skin of the neck, groin and axillae. She also reported new-onset heartburn, fatigue, and unintentional 15-kg weight loss. A skin biopsy of the facial lesion showed epidermal papillomatosis, acanthosis, hyperkeratosis, and negative staining for human papillomavirus. A computed tomography (CT) of the abdomen and pelvis was performed (right). What is the most likely diagnosis?
What is the most likely diagnosis?
Dermatology, Gastric adenocarcinoma, Malignant acanthosis nigricans, Paraneoplastic syndrome, Signet ring cell
