When COPD Treatment Affects the Voice

Explore the case of a 78-year-old man with COPD on inhaled steroids who develops dysphonia. Learn about the diagnostic process for white laryngeal plaques.

Laryngeal candidiasis


A 78-year-old man with chronic obstructive pulmonary disease (COPD) presented with a 2-month history of dysphonia. For the past 10 years, he had used an inhaled glucocorticoid daily to manage his COPD. Fiberoptic laryngoscopy revealed white plaques on both vocal cords. A biopsy showed hyperkeratinized stratified squamous epithelium and threadlike filaments that stained with Grocott-Gomori methenamine silver stain. What is the most likely diagnosis?

What is the most likely diagnosis?

Laryngeal amyloidosis
Laryngeal candidiasis
Laryngeal papillomatosis
Leukoplakia
Vocal-cord dysfunction

COPD, Dysphonia, Grocott-Gomori stain, Inhaled corticosteroids, Laryngeal candidiasis

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