When Kidneys Fail and Systems Flare

Explore a complex case of a man with acute Renal Failure, constitutional symptoms, and multi-organ involvement. Uncover the key autoantibody in this vasculitis.

Antineutrophil cytoplasmic autoantibody


Which one of the following is likely to be positive in a man with acute renal failure and these findings?

What is the most likely diagnosis?

IgA anti-tissue transglutaminase
IgG antibodies against Lyme disease
Helicobacter pylori stool antigen
Antimitochondrial antibodies
Antineutrophil cytoplasmic autoantibody

Acute Kidney Injury, Antineutrophil cytoplasmic autoantibody, Glomerulonephritis, Granulomatosis with polyangiitis, Vasculitis

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