When Skin Bumps Signal Cancer Risk

Explore the case of a 59-year-old man with facial trichilemmomas, lingual papillomas, and acral keratosis, pointing to a rare genetic disorder.

Cowden syndrome


A 59-year-old man with a remote history of melanoma presented to the dermatology clinic. He presented with lingual papillomas for many years, as well as multiple trichilemmomas on the face and chest, acral keratosis on the hands and feet, and macrocephaly. He also had a history of gastrointestinal polyps and a multinodular goiter. What is the diagnosis?

What is the most likely diagnosis?

Birt-Hogg Dube syndrome
Cowden syndrome
Tuberous sclerosis
Peutz-Jeghers syndrome
Hereditary mixed polyposis syndrome

Cowden syndrome, Genodermatosis, Hamartoma, PTEN, Trichilemmoma

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