Painful Vision: A Neurological Clue

A 13-year-old girl presents with painful, Blurry Vision and a history of leg weakness. Explore a case of optic neuritis and a relative afferent pupillary defect.

Multiple sclerosis


A 13-year-old girl presented with new onset blurry vision in the left eye associated with painful eye movements. Three weeks earlier, weakness and paresthesias had developed in her left leg that spontaneously resolved. When a light was swung from the normal right eye (Panel A) to the affected left eye, the left pupil dilated (Panel B) – a finding known as a relative afferent pupillary defect. Fundoscopic examination of both eyes was normal. Examination of the brain and whole spine by means of magnetic resonance imaging showed multiple, oblong hyperintense lesions on T2-weighted images. What is the most likely etiology?

What is the most likely diagnosis?

Acute disseminated encephalomyelitis
Leber hereditary optic neuropathy
Mononeuritis multiplex
Multiple sclerosis
Retinal detachment

Demyelination, Multiple sclerosis, Oligoclonal Bands, Optic Neuritis, Relative Afferent Pupillary Defect

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